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LobarNecrosisfromPulmonaryEmbolismRamiroFernandez,JonathanM.Tomasko,DaphneEdgren,etalAmJRespirCritCareMed;:-

A63-year-oldmalehearttransplantrecipientwithrecurrentlowerextremitydeepveinthrombosis,receivingwarfarin,withchronicallyreducedglomerularfiltrationrate(30ml/min),presentedwithworseningcoughanddyspnea.Laboratorytestingrevealednormalbloodcellcounts,mildlyelevatedC-reactiveprotein,andinternationalnormalizedratioof1.8.Subsequentradiographrevealedamiddlelobecavity(Figure1A).BronchoalveolarfluidculturesrevealedCandidaalbicans,butantifungaltherapyclearedtheorganismafter2weeks.Nevertheless,thecoughpersisted,andthecavityprogressedoverthefollowing6weeks(Figure1B).Giventheuncertainetiologyofthecavityandpersistenceofsymptoms,thoracoscopicmiddlelobectomywasperformed,duringwhichthemajorityofthelobewasfoundtobenecroticandfilledwith~10mlofthickbrownliquefieddebris.Majorandminorfissureswere“







































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